Possible anti-recombinogenic role of Bloom’s syndrome helicase in double-strand break processing

Bloom’s syndrome (BS) which associates genetic instability and predisposition to cancer is caused by mutations in the BLM gene encoding a RecQ family 3′–5′ DNA helicase. It has been proposed that the generation of genetic instability in BS cells could result from an aberrant non-homologous DNA end j...

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Hauptverfasser: Onclercq-Delic, Rosine, Calsou, Patrick, Delteil, Christine, Salles, Bernard, Papadopoulo, Dora, Amor-Guéret, Mounira
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2003
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC275476/
https://ncbi.nlm.nih.gov/pubmed/14576316
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg834
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