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Proteomic Characterization of Lipid Raft Proteins in ALS Mouse Spinal Cord

Familial amyotrophic lateral sclerosis (ALS) has been linked to mutations in the copper/zinc superoxide dismutase (SOD1) gene. The mutant SOD1 protein exhibits a toxic gain-of-function that adversely affects the function of neurons. However, the mechanism of how mutant SOD1 initiates ALS is unclear....

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Autores principales: Zhai, Jianjun, Ström, Anna-Lena, Kilty, Renee, Venkatakrishnan, Priya, White, James, Everson, William V., Smart, Eric J., Zhu, Haining
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2754564/
https://ncbi.nlm.nih.gov/pubmed/19438725
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1742-4658.2009.07057.x
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