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Functional dissection of the mouse tyrosinase locus control region identifies a new putative boundary activity

Locus control regions (LCRs) are complex high-order chromatin structures harbouring several regulatory elements, including enhancers and boundaries. We have analysed the mouse tyrosinase LCR functions, in vitro, in cell lines and, in vivo, in transgenic mice and flies. The LCR-core (2.1 kb), located...

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Autors principals: Giraldo, Patricia, Martínez, Antonio, Regales, Lucía, Lavado, Alfonso, García-Díaz, Angel, Alonso, Ángel, Busturia, Ana, Montoliu, Lluís
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2003
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC275449/
https://ncbi.nlm.nih.gov/pubmed/14576318
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkg793
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