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Virus Attenuation by Genome-Scale Changes in Codon Pair Bias

As a result of the redundancy of the genetic code, adjacent pairs of amino acids can be encoded by as many as 36 different pairs of synonymous codons. A species-specific “codon pair bias” provides that some synonymous codon pairs are used more or less frequently than statistically predicted. We synt...

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Bibliographic Details
Main Authors: Coleman, J. Robert, Papamichail, Dimitris, Skiena, Steven, Futcher, Bruce, Wimmer, Eckard, Mueller, Steffen
Format: Artigo
Language:Inglês
Published: 2008
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2754401/
https://ncbi.nlm.nih.gov/pubmed/18583614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1155761
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