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Eme1 is involved in DNA damage processing and maintenance of genomic stability in mammalian cells

Yeast and human Eme1 protein, in complex with Mus81, constitute an endonuclease that cleaves branched DNA structures, especially those arising during stalled DNA replication. We identified mouse Eme1, and show that it interacts with Mus81 to form a complex that preferentially cleaves 3′-flap structu...

Ausführliche Beschreibung

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Veröffentlicht in:EMBO J
Hauptverfasser: Abraham, Jacinth, Lemmers, Bénédicte, Hande, M.Prakash, Moynahan, Mary Ellen, Chahwan, Charly, Ciccia, Alberto, Essers, Jeroen, Hanada, Katsuhiro, Chahwan, Richard, Khaw, Aik Kia, McPherson, Peter, Shehabeldin, Amro, Laister, Rob, Arrowsmith, Cheryl, Kanaar, Roland, West, Stephen C., Jasin, Maria, Hakem, Razqallah
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2003
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Articles
Online-Zugang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC275438/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/14609959/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/emboj/cdg580
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