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The Sequence Specificity of Homeodomain-DNA Interaction

The Drosophila developmental gene, engrailed, encodes a sequence-specific DNA binding activity. Using deletion constructs expressed as fusion proteins in E. coli, we localized this activity to the conserved homeodomain (HD). The binding site consensus, TCAATTAAAT, is found in clusters in the engrail...

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Main Authors: Desplan, Claude, Theis, Jim, O’Farrell, Patrick H.
格式: Artigo
語言:Inglês
出版: 1988
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2753412/
https://ncbi.nlm.nih.gov/pubmed/3046753
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