Catechol-O-Methyltransferase Expression and 2-Methoxyestradiol Affect Microtubule Dynamics and Modify Steroid Receptor Signaling in Leiomyoma Cells

CONTEXT: Development of optimal medicinal treatments of uterine leiomyomas represents a significant challenge. 2-Methoxyestradiol (2ME) is an endogenous estrogen metabolite formed by sequential action of CYP450s and catechol-O-methyltransferase (COMT). Our previous study demonstrated that 2ME is a p...

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Main Authors: Salama, Salama A., Kamel, Marwa W., Botting, Shaleen, Salih, Sana M., Borahay, Mostafa A., Hamed, Ahmed A., Kilic, Gokhan S., Saeed, Muhammad, Williams, Marian Y., Diaz-Arrastia, Concepcion R.
Formáid: Artigo
Teanga:Inglês
Foilsithe: Public Library of Science 2009
Ábhair:
Research Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2752809/
https://ncbi.nlm.nih.gov/pubmed/19809499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0007356
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