Structure-based Design, Synthesis, Biochemical and Pharmacological Characterization of Novel Salvinorin A Analogues as Active State Probes of the κ-Opioid Receptor

Salvinorin A, the most potent naturally occurring hallucinogen, has gained increasing attention since the κ-opioid receptor (KOR) was identified as its principal molecular target by us (Roth et al, PNAS, 2002). Here we report the design, synthesis and biochemical characterization of novel, irreversi...

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Detaylı Bibliyografya
Asıl Yazarlar: Yan, Feng, Bikbulatov, Ruslan V., Mocanu, Viorel, Dicheva, Nedyalka, Parker, Carol E., Wetsel, William C., Mosier, Philip D., Westkaemper, Richard B., Allen, John A., Zjawiony, Jordan K., Roth, Bryan L.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2009
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2752672/
https://ncbi.nlm.nih.gov/pubmed/19555087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi900605n
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