aPKCλ/ι promotes growth of prostate cancer cells in an autocrine manner through transcriptional activation of interleukin-6

Understanding the mechanism by which hormone refractory prostate cancer (HRPC) develops remains a major issue. Alterations in HRPC include androgen receptor (AR) changes. In addition, the AR is activated by cytokines such as interleukin-6 (IL-6). Atypical protein kinase C (aPKCλ/ι) has been implicat...

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Detalles Bibliográficos
Autores principales: Ishiguro, Hitoshi, Akimoto, Kazunori, Nagashima, Yoji, Kojima, Yasuyuki, Sasaki, Takeshi, Ishiguro-Imagawa, Yukari, Nakaigawa, Noboru, Ohno, Shigeo, Kubota, Yoshinobu, Uemura, Hiroji
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2009
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2752573/
https://ncbi.nlm.nih.gov/pubmed/19805306
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0907044106
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