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Endogenous glucocorticoids and impaired insulin signaling are both required to stimulate muscle wasting under pathophysiological conditions in mice

Muscle wasting is associated with a number of pathophysiologic conditions, including metabolic acidosis, diabetes, sepsis, and high angiotensin II levels. Under these conditions, activation of muscle protein degradation requires endogenous glucocorticoids. As the mechanism(s) underlying this depende...

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Bibliografische gegevens
Hoofdauteurs: Hu, Zhaoyong, Wang, Huiling, Lee, In Hee, Du, Jie, Mitch, William E.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2009
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2752071/
https://ncbi.nlm.nih.gov/pubmed/19759515
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38770
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