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A Continuous Microplate Assay for Sirtuins and Nicotinamide Producing Enzymes

NAD(+)-dependent protein deacetylases (sirtuins) and other enzymes that produce nicotinamide are integral to many cellular processes. Yet current activity measurements involve expensive and time-consuming assays. Here, we present a spectroscopic assay that circumvents many issues of previous methods...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Smith, Brian C., Hallows, William C., Denu, John M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2009
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2752052/
https://ncbi.nlm.nih.gov/pubmed/19615966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ab.2009.07.019
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