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Catalytic mechanism of a MYST family histone acetyltransferase
Distinct catalytic mechanisms have been proposed for the Gcn5 and MYST histone acetyltransferases (HAT) families. Gcn5-like HATs utilize an ordered sequential mechanism involving direct nucleophilic attack of the N-ε-lysine on the enzyme-bound acetyl-CoA. Recently, MYST enzymes were reported to empl...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2007
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2752042/ https://ncbi.nlm.nih.gov/pubmed/17223684 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi602513x |
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