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Effect of N-1 and N-2 residues on peptide deamidation rate in solution and solid state
The deamidation kinetics of 7 model peptides (VYPNGA, VYGNGA, VFGNGA, VIGNGA, VGGNGA, VGPNGA, and VGYNGA) were studied at 70°C in pH 10 buffer solutions and at 70°C and 50% relative humidity in lyophilized solid formulations containing polyvinyl pyrrolidone (PVP). The disappearance of the model pept...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer-Verlag
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2751436/ https://ncbi.nlm.nih.gov/pubmed/16584125 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/aapsj080120 |
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