Metabolic Cleavage and Translocation Efficiency of Selected Cell Penetrating Peptides: A Comparative Study with Epithelial Cell Cultures

We investigated the metabolic stability of four cell penetrating peptides (CPPs), namely SAP, hCT(9-32)-br, [Pα] and [Pβ], when in contact with either subconfluent HeLa, confluent MDCK or Calu-3 epithelial cell cultures. Additionally, through analysis of their cellular translocation efficiency, we e...

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Main Authors: Foerg, Christina, Weller, Kathrin M., Rechsteiner, Helene, Nielsen, Hanne M., Fernández-Carneado, Jimena, Brunisholz, René, Giralt, Ernest, Merkle, Hans P.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer US 2008
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2751379/
https://ncbi.nlm.nih.gov/pubmed/18587651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/s12248-008-9029-4
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