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Pharmacologic and pharmacokinetic profile of repifermin (KGF-2) in monkeys and comparative pharmacokinetics in humans

Repifermin (truncated, recombinant human keratinocyte growth factor-2, KGF-2) was evaluated in cynomolgus monkeys and healthy humans during a phase 1 trial. Monkeys received vehicle or repifermin at 20, 75, or 200 μg/kg IV or 750 μg/kg subcutaneous (SC) daily for 29 days. Clinical observations were...

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Detalhes bibliográficos
Main Authors: Sung, Cynthia, Parry, Tom J., Riccobene, Todd A., Mahoney, Angela, Roschke, Viktor, Murray, James, Gu, Mi Li, Glenn, Jeffrey K., Caputo, Florence, Farman, Cindy, Odenheimer, Daniel J.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2751293/
https://ncbi.nlm.nih.gov/pubmed/12102616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/ps040206
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