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Evidence of effectiveness: How much can we extrapolate from existing studies?
Drug development can be a science of extrapolation if the use of a drug exposure-response relationship is embraced and implemented through mechanistically oriented pharmacokinetic (PK)-pharmacodynamic (PD) modeling analysis and clinical trial simulation. The traditional requirement of at least 2 ade...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer-Verlag
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2750984/ https://ncbi.nlm.nih.gov/pubmed/16353924 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1208/aapsj070247 |
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