Coexpression of the Type 2 Diabetes Susceptibility Gene Variants KCNJ11 E23K and ABCC8 S1369A Alter the ATP and Sulfonylurea Sensitivities of the ATP-Sensitive K(+) Channel

OBJECTIVE: In the pancreatic β-cell, ATP-sensitive K(+) (K(ATP)) channels couple metabolism with excitability and consist of Kir6.2 and SUR1 subunits encoded by KCNJ11 and ABCC8, respectively. Sulfonylureas, which inhibit the K(ATP) channel, are used to treat type 2 diabetes. Rare activating mutatio...

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Detalhes bibliográficos
Main Authors: Hamming, Kevin S.C., Soliman, Daniel, Matemisz, Laura C., Niazi, Omid, Lang, Yiqiao, Gloyn, Anna L., Light, Peter E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2009
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2750221/
https://ncbi.nlm.nih.gov/pubmed/19587354
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-0143
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