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Leptin increases osteoblast-specific osteocalcin release through a hypothalamic relay
Enhanced long-term expression of leptin by gene therapy selectively in the hypothalamus, without leakage to the systemic circulation, abrogated skeletal abnormalities and reinstated weight and insulin-glucose homeostasis in leptin deficient ob/ob mice. Whether increases in osteocalcin, a hormone pro...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2749976/ https://ncbi.nlm.nih.gov/pubmed/19428775 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.peptides.2009.01.020 |
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