Blockade of Cripto binding to cell surface GRP78 inhibits oncogenic Cripto signaling via MAPK/PI3K and Smad2/3 pathways

Cripto is a developmental oncoprotein that signals via MAPK/ERK, PI3K/Akt and Smad2/3 pathways. However, the molecular basis for Cripto coupling to these pathways during embryogenesis and tumorigenesis is not fully understood. In this regard, we recently demonstrated that Cripto forms a cell surface...

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Autores principales: Kelber, JA, Panopoulos, AD, Shani, G, Booker, EC, Belmonte, JC, Vale, WW, Gray, PC
Formato: Artigo
Lenguaje:Inglês
Publicado: 2009
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2749668/
https://ncbi.nlm.nih.gov/pubmed/19421146
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.97
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