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Local DNA Topography Correlates with Functional Noncoding Regions of the Human Genome
The three-dimensional molecular structure of DNA, specifically the shape of the backbone and grooves of genomic DNA, can be dramatically affected by nucleotide changes, which can cause differences in protein binding affinity and phenotype. We developed an algorithm to measure constraint on the basis...
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| Autori principali: | , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2009
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2749491/ https://ncbi.nlm.nih.gov/pubmed/19286520 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1169050 |
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