Crystal Structures of the Reduced, Sulfenic Acid, and Mixed Disulfide Forms of SarZ, a Redox Active Global Regulator in Staphylococcus aureus

SarZ is a global transcriptional regulator that uses a single cysteine residue, Cys(13), to sense peroxide stress and control metabolic switching and virulence in Staphylococcus aureus. SarZ belongs to the single-cysteine class of OhrR-MgrA proteins that play key roles in oxidative resistance and vi...

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Bibliographische Detailangaben
Hauptverfasser: Poor, Catherine B., Chen, Peng R., Duguid, Erica, Rice, Phoebe A., He, Chuan
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2009
Schlagworte:
Protein Structure and Folding
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2749125/
https://ncbi.nlm.nih.gov/pubmed/19586910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.015826
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