Negative Guidance Factor-Induced Macropinocytosis in the Growth Cone Plays a Critical Role in Repulsive Axon Turning

Macropinocytosis is a type of poorly characterized fluid-phase endocytosis that results in formation of relatively large vesicles. We report that Sonic hedgehog (Shh) protein induces macropinocytosis in the axons through activation of a noncanonical signaling pathway, including Rho GTPase and nonmus...

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Hauptverfasser: Kolpak, Adrianne L., Jiang, Jun, Guo, Daorong, Standley, Clive, Bellve, Karl, Fogarty, Kevin, Bao, Zheng-Zheng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2009
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2748960/
https://ncbi.nlm.nih.gov/pubmed/19710302
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2355-09.2009
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