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Ambivalent Incorporation of the Fluorescent Cytosine Analogues tC and tCo by Human DNA Polymerase α and Klenow Fragment

We studied the incorporation of the fluorescent cytidine analogues 1, 3-diaza-2-oxo-phenothiazine (tC) and 1, 3-diaza-2-oxo-phenoxazine (tCo) by human DNA polymerase α and Klenow fragment of DNA polymerase I (E. coli). These tricyclic nucleobases possess the regular hydrogen bonding interface of cyt...

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Detalhes bibliográficos
Main Authors: Stengel, Gudrun, Purse, Byron W., Wilhelmsson, L. Marcus, Urban, Milan, Kuchta, Robert D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2748917/
https://ncbi.nlm.nih.gov/pubmed/19580325
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi9006995
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