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tRNA–mRNA mimicry drives translation initiation from a viral IRES

Internal ribosome entry site (IRES) RNAs initiate protein synthesis in eukaryotic cells by a noncanonical cap-independent mechanism. IRESes are critical for many pathogenic viruses, but efforts to understand their function are complicated by the diversity of IRES sequences as well as by limited high...

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Bibliographic Details
Main Authors: Costantino, David A, Pfingsten, Jennifer S, Rambo, Robert P, Kieft, Jeffrey S
Format: Artigo
Language:Inglês
Published: 2007
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2748805/
https://ncbi.nlm.nih.gov/pubmed/18157151
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb1351
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