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Structural Basis for Ribosome Recruitment and Manipulation by a Viral IRES RNA

Canonical cap-dependent translation initiation requires a large number of protein factors that act in a stepwise assembly process. In contrast, internal ribosomal entry sites (IRESs) are cis-acting RNAs that in some cases completely supplant these factors by recruiting and activating the ribosome us...

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Detalhes bibliográficos
Main Authors: Pfingsten, Jennifer S., Costantino, David A., Kieft, Jeffrey S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2669756/
https://ncbi.nlm.nih.gov/pubmed/17124290
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1133281
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