Influence of Enzyme-Inducing Antiepileptic Drugs on Trough Level of Imatinib in Glioblastoma Patients

BACKGROUND: Imatinib mesylate is used in combination with hydroxyurea (HU) in ongoing clinical phase II studies in recurrent glioblastoma multiforme (GBM). CYP3A4 enzyme-inducing antiepileptic drugs (EIAEDs) like carbamazepine, phenytoin, and oxcarbazepine - as well as non-EIAEDs like valproic acid,...

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Detalhes bibliográficos
Main Authors: Pursche, Stefan, Schleyer, Eberhard, von Bonin, Malte, Ehninger, Gerhard, Said, Samir Mustafa, Prondzinsky, Roland, Illmer, Thomas, Wang, Yanfeng, Hosius, Christian, Nikolova, Zariana, Bornhäuser, Martin, Dresemann, Gregor
Formato: Artigo
Idioma:Inglês
Publicado em: Bentham Science Publishers Ltd. 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2748699/
https://ncbi.nlm.nih.gov/pubmed/18781906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2174/157488408785747656
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