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yFACT Induces Global Accessibility of Nucleosomal DNA Without H2A–H2B Displacement

FACT has been proposed to function by displacing an H2A–H2B dimer to form hexasomes. Results described here with yeast FACT (yFACT) suggest instead that nucleosomes are reorganized to a form with the original composition but a looser, more dynamic structure. First, yFACT enhances hydroxyl radical ac...

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Bibliografiske detaljer
Main Authors: Xin, Hua, Takahata, Shinya, Blanksma, Mary, McCullough, Laura, Stillman, David J., Formosa, Tim
Format: Artigo
Sprog:Inglês
Udgivet: 2009
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2748400/
https://ncbi.nlm.nih.gov/pubmed/19683499
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.06.024
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