Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation

The serine/threonine protein kinase B (PKB, also known as Akt) plays a pivotal role in diverse cellular functions. Elevated expression of activated Akt has been detected in a wide variety of human cancers; however, the mechanism of Akt protein stability regulation remains unclear. In this study, we...

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Main Authors: Liao, Y, Wei, Y, Zhou, X, Yang, J-Y, Dai, C, Chen, Y-J, Agarwal, NK, Sarbassov, D, Shi, D, Yu, D, Hung, M-C
Format: Artigo
Jezik:Inglês
Izdano: 2009
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2748248/
https://ncbi.nlm.nih.gov/pubmed/19448664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/onc.2009.98
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