The Size of the Viral Inoculum Contributes to the Outcome of Hepatitis B Virus Infection

The impact of virus dose on the outcome of infection is poorly understood. In this study we show that, for hepatitis B virus (HBV), the size of the inoculum contributes to the kinetics of viral spread and immunological priming, which then determine the outcome of infection. Adult chimpanzees were in...

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Bibliographic Details
Main Authors: Asabe, Shinichi, Wieland, Stefan F., Chattopadhyay, Pratip K., Roederer, Mario, Engle, Ronald E., Purcell, Robert H., Chisari, Francis V.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2009
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2748002/
https://ncbi.nlm.nih.gov/pubmed/19625407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00867-09
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