Derivation and Characterization of a Simian Immunodeficiency Virus SIVmac239 Variant with Tropism for CXCR4

Like human immunodeficiency virus type 1 (HIV-1), most simian immunodeficiency virus (SIV) strains use CCR5 to establish infection. However, while HIV-1 can acquire the ability to use CXCR4, SIVs that utilize CXCR4 have rarely been reported. To explore possible barriers against SIV coreceptor switch...

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Main Authors: Del Prete, Gregory Q., Haggarty, Beth, Leslie, George J., Jordan, Andrea P. O., Romano, Josephine, Wang, Nathaniel, Wang, Jianbin, Holmes, Michael C., Montefiori, David C., Hoxie, James A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2009
Assuntos:
Pathogenesis and Immunity
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2748001/
https://ncbi.nlm.nih.gov/pubmed/19605489
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00533-09
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