Enantioselective Synthesis of (+)-Chamaecypanone C, a Novel Microtubule Inhibitor

A number of bicyclo[2.2.2]octenone-containing natural products have been isolated from the heartwood of Chamaecyparis obtusa var. formosana (Figure 1) including the Diels-Alder adducts[1] obtunone (1),[2] chamaecypanone C (2),[3] and the [4+2] dimer (+)-3.[2],[4] Compound (+)-2 was shown to exhibit...

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Hlavní autoři: Dong, Suwei, Hamel, Ernest, Bai, Ruoli, Covell, David G., Beutler, John A., Porco, John A.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2009
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2747729/
https://ncbi.nlm.nih.gov/pubmed/19140149
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.200805486
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