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Tracking the cell cycle origins for escape from topotecan action by breast cancer cells
The anticancer agent topotecan is considered to be S-phase specific. This implies that cancer cells that are not actively replicating DNA could resist the effects of the drug. The cycle specificity of topotecan action was investigated in MCF-7 cells, using time-lapse microscopy to link the initial c...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group
2003
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2747574/ https://ncbi.nlm.nih.gov/pubmed/12698201 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600889 |
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