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Reduced endocytosis and altered lysosome function in cisplatin-resistant cell lines
We isolated human KB adenocarcinoma cisplatin-resistant (CP-r) cell lines with multidrug-resistance phenotypes because of reduced accumulation of cisplatin and other cytotoxic compounds such as methotrexate and heavy metals. The uptake of horseradish peroxidase (HRPO) and Texas Red dextran was decre...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2003
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2747565/ https://ncbi.nlm.nih.gov/pubmed/12698203 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600861 |
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