Reduced endocytosis and altered lysosome function in cisplatin-resistant cell lines

We isolated human KB adenocarcinoma cisplatin-resistant (CP-r) cell lines with multidrug-resistance phenotypes because of reduced accumulation of cisplatin and other cytotoxic compounds such as methotrexate and heavy metals. The uptake of horseradish peroxidase (HRPO) and Texas Red dextran was decre...

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Bibliografiske detaljer
Main Authors: Chauhan, S S, Liang, X J, Su, A W, Pai-Panandiker, A, Shen, D W, Hanover, J A, Gottesman, M M
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2003
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2747565/
https://ncbi.nlm.nih.gov/pubmed/12698203
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600861
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