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Total Synthesis of Indolizidine Alkaloid (−)-209D: Overriding Substrate Bias in the Asymmetric Rhodium-Catalyzed [2+2+2] Cycloaddition

[Image: see text] CO! You had me at hello The use of chiral biphenyl-based phosphoramidite ligands on rhodium provides an efficient [2+2+2] cycloaddition between terminal alkyl alkynes and alkenyl isocyanates. The cycloaddition proceeds through a CO migration pathway, and facilitates a rapid four-st...

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Detalhes bibliográficos
Main Authors: Yu, Robert T., Lee, Ernest E., Malik, Guillaume, Rovis, Tomislav
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2747357/
https://ncbi.nlm.nih.gov/pubmed/19229912
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.200805455
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