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Recognition of Abasic Sites and Single Base Bulges in DNA by a Metalloinsertor

Abasic sites and single base bulges are thermodynamically destabilizing DNA defects that can lead to cancerous transformations if left unrepaired by the cell. Here we discuss the binding properties with abasic sites and single base bulges of Rh(bpy)(2)(chrysi)(3+), a complex previously shown to bind...

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Main Authors: Zeglis, Brian M., Boland, Jennifer A., Barton, Jacqueline K.
格式: Artigo
語言:Inglês
出版: 2009
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2747346/
https://ncbi.nlm.nih.gov/pubmed/19146409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi801885w
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