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Validating GSK3 as an in vivo target of lithium action
Lithium is widely used to treat bipolar disorder, but its mechanism of action in this disorder is unknown. Lithium directly inhibits glycogen synthase kinase-3 (GSK3), a critical regulator of multiple signal transduction pathways. Inhibition of GSK3 provides a compelling explanation for many of the...
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| Principais autores: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2009
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2747042/ https://ncbi.nlm.nih.gov/pubmed/19754466 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BST0371133 |
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