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G-quadruplex recognition by bis-indole carboxamides
Herein we report the de novo design and synthesis of a geometrically flexible bis-indole carboxamide and a constrained derivative, as a novel class of small molecule scaffold that exhibits high stabilization potential for DNA G-quadruplex sequences associated with the promoters of c-kit2 and c-myc.
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2746961/ https://ncbi.nlm.nih.gov/pubmed/18688346 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/b806042h |
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