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Blockade of androgen receptors is sufficient to alter the sexual differentiation of the substantia nigra pars reticulata seizure-controlling network

The substantia nigra pars reticulata (SNR) controls seizures in a sex-specific manner. At postnatal day 15 (P15), SNR infusion of GABA(A) receptor agonist muscimol have proconvulsant effects in males but not in females. In males, administration of an androgen receptor antagonist flutamide between P0...

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Detalhes bibliográficos
Main Authors: Heida, James G., Velíšková, Jana, Moshé, Solomon L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2746950/
https://ncbi.nlm.nih.gov/pubmed/18367425
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1684/epd.2008.0160
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