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Polo kinase and separase regulate the mitotic licensing of centriole duplication in human cells

It has been proposed that separase-dependent centriole disengagement at anaphase licenses centrosomes for duplication in the next cell cycle. Here we test whether such a mechanism exists in intact human cells. Loss of separase blocked centriole disengagement during mitotic exit and delayed assembly...

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Detalles Bibliográficos
Main Authors: Tsou, Meng-Fu Bryan, Wang, Won-Jing, Yule, Kelly A., Uryu, Kunihiro, Stearns, Tim, Jallepalli, Prasad V.
Formato: Artigo
Idioma:Inglês
Publicado: 2009
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2746921/
https://ncbi.nlm.nih.gov/pubmed/19758559
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2009.07.015
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