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Polo kinase and separase regulate the mitotic licensing of centriole duplication in human cells
It has been proposed that separase-dependent centriole disengagement at anaphase licenses centrosomes for duplication in the next cell cycle. Here we test whether such a mechanism exists in intact human cells. Loss of separase blocked centriole disengagement during mitotic exit and delayed assembly...
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| Hauptverfasser: | , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2009
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2746921/ https://ncbi.nlm.nih.gov/pubmed/19758559 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2009.07.015 |
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