A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis

Chronic pancreatitis (CP) is a common inflammatory disease of the pancreas. Mutations in the genes encoding cationic trypsinogen (PRSS1)1 and the pancreatic secretory trypsin inhibitor (SPINK1)2 are associated with CP. Since increased proteolytic activity due to mutated PRSS1 enhances the risk for C...

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Main Authors: Witt, Heiko, Sahin-Tóth, Miklós, Landt, Olfert, Chen, Jian-Min, Kähne, Thilo, Drenth, Joost PH, Kukor, Zoltán, Szepessy, Edit, Halangk, Walter, Dahm, Stefan, Rohde, Klaus, Schulz, Hans-Ulrich, Maréchal, Cédric Le, Akar, Nejat, Ammann, Rudolf W, Truninger, Kaspar, Bargetzi, Mario, Bhatia, Eesh, Castellani, Carlo, Cavestro, Giulia Martina, Cerny, Milos, Destro-Bisol, Giovanni, Spedini, Gabriella, Eiberg, Hans, Jansen, Jan BMJ, Koudova, Monika, Rausova, Eva, Macek, Milan, Malats, Núria, Real, Francisco X, Menzel, Hans-Jürgen, Moral, Pedro, Galavotti, Roberta, Pignatti, Pier Franco, Rickards, Olga, Spicak, Julius, Zarnescu, Narcis Octavian, Böck, Wolfgang, Gress, Thomas M, Friess, Helmut, Ockenga, Johann, Schmidt, Hartmut, Pfützer, Roland, Löhr, Matthias, Simon, Peter, Weiss, Frank Ulrich, Lerch, Markus M, Teich, Niels, Keim, Volker, Berg, Thomas, Wiedenmann, Bertram, Luck, Werner, Groneberg, David Alexander, Becker, Michael, Keil, Thomas, Kage, Andreas, Bernardova, Jana, Braun, Markus, Güldner, Claudia, Halangk, Juliane, Rosendahl, Jonas, Witt, Ulrike, Treiber, Matthias, Nickel, Renate, Férec, Claude
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2746914/
https://ncbi.nlm.nih.gov/pubmed/16699518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng1797
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