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Local tetrahydrobiopterin administration augments cutaneous vasoconstriction in aged humans
Reflex vasoconstriction (VC) is attenuated in aged skin resulting in greater skin blood flow and heat loss during cold exposure. We hypothesized that adrenergic function is compromised due to depletion of tetrahydrobiopterin (BH(4)), an essential cofactor required for catecholamine synthesis, and th...
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| Asıl Yazarlar: | , , |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
Blackwell Science Inc
2009
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2746623/ https://ncbi.nlm.nih.gov/pubmed/19491246 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2009.173815 |
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