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Local tetrahydrobiopterin administration augments cutaneous vasoconstriction in aged humans
Reflex vasoconstriction (VC) is attenuated in aged skin resulting in greater skin blood flow and heat loss during cold exposure. We hypothesized that adrenergic function is compromised due to depletion of tetrahydrobiopterin (BH(4)), an essential cofactor required for catecholamine synthesis, and th...
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| Main Authors: | , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
Blackwell Science Inc
2009
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2746623/ https://ncbi.nlm.nih.gov/pubmed/19491246 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2009.173815 |
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