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Potassium channel opening: a subtle two-step

Voltage-gated K(+) channels undergo a voltage-dependent conductance change that plays a key role in modulating cellular excitability. While the Open state is captured in crystal structures of Kv1.2 and a chimeric Kv1.2/Kv2.1 channel, the Close state and the mechanism of this transition are still a s...

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Autori principali: Upadhyay, Sanjeev K, Nagarajan, P, Mathew, M K
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Science Inc 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2746614/
https://ncbi.nlm.nih.gov/pubmed/19528245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2009.174730
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