Induction of DNA breaks and apoptosis in crosslink-hypersensitive V79 cells by the cytostatic drug β-D-glucosyl-ifosfamide mustard

To study molecular aspects of cytotoxicity of the anticancer drug β-D-glucose-ifosfamide mustard we investigated the potential of the agent to induce apoptosis and DNA breakage. Since β-D-glucose-ifosfamide mustard generates DNA interstrand crosslinks, we used as an in vitro model system a pair of i...

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Bibliografische gegevens
Hoofdauteurs: Becker, R, Ritter, A, Eichhorn, U, Lips, J, Bertram, B, Wiessler, M, Zdzienicka, M Z, Kaina, B
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Nature Publishing Group 2002
Onderwerpen:
Experimental Therapeutics
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2746532/
https://ncbi.nlm.nih.gov/pubmed/11857024
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6600027
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