Non-enzymatic glycation of type I collagen diminishes collagen-proteoglycan binding and weakens cell adhesion

Non-enzymatic glycation of type I collagen occurs in aging and diabetes, and may affect collagen solubility, charge, polymerization, and intermolecular interactions. Proteoglycans(PGs) bind type I collagen and are proposed to regulate fibril assembly, function, and cell-collagen interactions. Moreov...

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Autori principali: Reigle, Kristin L., Di Lullo, Gloria, Turner, Kevin R., Last, Jerold A., Chervoneva, Inna, Birk, David E., Funderburgh, James L., Elrod, Elizabeth, Germann, Markus W., Surber, Charles, Sanderson, Ralph D., San Antonio, James D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2008
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2746388/
https://ncbi.nlm.nih.gov/pubmed/18348167
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.21735
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