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Relationship between circadian oscillations of Rev-erbα expression and intracellular levels of its ligand, heme

The nuclear hormone receptors, REV-ERBα [NR1D1] and REV-ERBβ [NR1D1], were recently demonstrated to be receptors for the porphyrin, heme. Heme regulates the ability of these receptors to repress transcription of their target genes via modulation of the affinity of the receptor's ligand binding...

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Bibliografiske detaljer
Main Authors: Rogers, Pamela M., Ying, Ling, Burris, Thomas P.
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2746331/
https://ncbi.nlm.nih.gov/pubmed/18280802
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2008.02.031
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