An orally effective dihydropyrimidone (DHPM) analogue induces apoptosis-like cell death in clinical isolates of Leishmania donovani overexpressing pteridine reductase 1

The protozoan parasite Leishmania donovani is the causative agent of visceral leishmaniasis. The enzyme pteridine reductase 1 (PTR1) of L. donovani acts as a metabolic bypass for drugs targeting dihydrofolate reductase (DHFR); therefore, for successful antifolate chemotherapy to be developed against...

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Detalhes bibliográficos
Main Authors: Singh, Neeloo, Kaur, Jaspreet, Kumar, Pranav, Gupta, Swati, Singh, Nasib, Ghosal, Angana, Dutta, Avijit, Kumar, Ashutosh, Tripathi, RamaPati, Siddiqi, Mohammad Imran, Mandal, Chitra, Dube, Anuradha
Formato: Artigo
Idioma:Inglês
Publicado em: Springer-Verlag 2009
Assuntos:
Original Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2745541/
https://ncbi.nlm.nih.gov/pubmed/19621245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00436-009-1557-z
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