Akt and 14-3-3 control a PACS-2 homeostatic switch that integrates membrane traffic with TRAIL-induced apoptosis

TRAIL selectively kills diseased cells in vivo, spurring interest in this death ligand as a potential therapeutic. However, many cancer cells are resistant to TRAIL suggesting the mechanism mediating TRAIL-induced apoptosis is complex. Here we identify PACS-2 as an essential TRAIL effector, required...

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Autori principali: Aslan, Joseph E., You, Huihong, Williamson, Danielle M., Endig, Jessica, Youker, Robert T., Thomas, Laurel, Shu, Hongjun, Du, Yuhong, Milewski, Robert L., Brush, Matthew H., Possemato, Anthony, Sprott, Kam, Fu, Haian, Greis, Kenneth D., Runckel, Douglas N., Vogel, Arndt, Thomas, Gary
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2744858/
https://ncbi.nlm.nih.gov/pubmed/19481529
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2009.04.011
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