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Inhibiting caspase-3 activity blocks beta-catenin degradation after focal ischemia in rat
Beta-catenin can be cleaved by caspase-3 or degraded by activated glycogen synthase kinase-3β via phosphorylating β-catenin. We tested the hypothesis that β-catenin undergoes degradation after stroke, and its degradation is dependent on caspase activity. Stroke was generated by permanent middle cere...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2008
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2744604/ https://ncbi.nlm.nih.gov/pubmed/18463494 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/WNR.0b013e3282ffda72 |
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