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Hypothermia Blocks β-catenin Degradation after Focal Ischemia in Rats
Dephosphorylated and activated glycogen synthase kinase (GSK) 3β hyperphophorylates β-catenin, leading to its ubiquitin-proteosome-mediated degradation. β-catenin-knockdown increases while β-catenin overexpression prevents neuronal death in vitro; in addition, protein levels of β-catenin are reduced...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2350209/ https://ncbi.nlm.nih.gov/pubmed/18241848 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2008.01.007 |
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