Hypothermia Blocks β-catenin Degradation after Focal Ischemia in Rats

Dephosphorylated and activated glycogen synthase kinase (GSK) 3β hyperphophorylates β-catenin, leading to its ubiquitin-proteosome-mediated degradation. β-catenin-knockdown increases while β-catenin overexpression prevents neuronal death in vitro; in addition, protein levels of β-catenin are reduced...

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Bibliografiske detaljer
Main Authors: Zhang, Hanfeng, Ren, Chuancheng, Gao, Xuwen, Takahashi, Tetsuya, Sapolsky, Robert M., Steinberg, Gary K., Zhao, Heng
Format: Artigo
Sprog:Inglês
Udgivet: 2008
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2350209/
https://ncbi.nlm.nih.gov/pubmed/18241848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.brainres.2008.01.007
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